In November our MitAD team published a review article on Compromised autophagy and mitophagy in brain ageing and Alzheimer’s diseases in Aging Brain (an Open Access journal that complements Neurobiology of Aging).
In this review, we give an overview of autophagy and mitophagy and their link to the progression of AD. We also summarize approaches to upregulate autophagy/mitophagy. We hypothesize that age-dependent compromised autophagy/mitophagy is a cause of brain ageing and a risk factor for AD, while restoration of autophagy/mitophagy to more youthful levels could return the brain to health.
Please find the full-text here.